Anne Hampton Potts (born October 28, 1952) is an American actress. She was nominated for a Golden Globe Award for Corvette Summer (1978) and won a Genie Award for Heartaches (1981), before appearing in Ghostbusters (1984), Pretty in Pink (1986), Jumpin' Jack Flash (1986), Who's Harry Crumb? (1989), Ghostbusters II (1989), Ghostbusters: Afterlife (2021), and Ghostbusters: Frozen Empire (2024). She voiced Bo Peep in the first, second and fourth films of the Toy Story franchise (1995, 1999, and 2019) and in various Disney video games.

On television, she played Mary Jo Jackson Shively on the CBS sitcom Designing Women (1986–1993). She was nominated for a 1994 Primetime Emmy Award for playing Dana Palladino on the CBS sitcom Love & War (1993–1995), she played teacher Louanne Johnson on ABC drama Dangerous Minds for one season 1996–1997, and was nominated for Screen Actors Guild Awards in 1998 and 1999 for playing Mary-Elizabeth "M.E" Sims in the Lifetime drama series Any Day Now (1998–2002). Her other television credits include GCB (2012), The Fosters (2013–2018), and Young Sheldon (2017–2024).

She was married to her 1st husband Steven Hartley from 1973 to 1978; her 2nd husband, actor Greg Antonacci from 1978 to 1980; and her 3rd husband Scott Senechal from 1981 to 1989, and they have 1 son. She married her 4th husband, director/producer James Hayman in 1990 and they have 2 sons. ​