Born May 28, 1962 in Novosibirsk, grew up in the city of Kemerovo.

In Kemerovo he graduated from the directing department of the Institute of Culture. For some time the actor worked at the Minusinsk Theater.

In 1990 he graduated from the Moscow Art Theater School (workshop of Alexander Kalyagin) and became an actor of the Moscow Art Theater named after A.P. Chekhov.

Among his stage works are "Three Sisters" (Salty), "The Miserly Knight", "Marriage", the performance of the Tabakov Theater-Studio "Deadly Number", the private production of "Winter" by Evgeny Grishkovets, the sensational "Academy of Laughter" and "Three on swing" in the theater named after A.S. Pushkin. One of the first film roles Andrei Panin played in the film "In a straight line." But the actor gained fame thanks to the films "Mother, Do not Cry" by Maxim Pezhemsky, "Mother" by Denis Evstigneev, the television series "Kamenskaya" and "Border. Taiga Romance". In 2000, Andrei Panin played in the films "Wedding" by Pavel Lungin and "It is not recommended to offend women" by Valery Akhadov, as well as in the action movie "24 hours" by Alexander Atanesyan. The success of the series "Brigada" also contributed to the popularity of Andrei Panin. He also starred in such popular films as "Chic", "A Horseman Called Death", "Don't Even Think 2: Shadow of Independence", "Driver for Faith", "Shadow Boxing", "Blind Man's Buff", "Mom, Don't Cry -2".

In 2006 he graduated from the experimental acting workshop at VGIK.

Honored Artist of the Russian Federation (1999).

He passed away on March 6, 2013 in Moscow.

He was buried on March 12 at the Troekurovsky cemetery of the capital (site No. 6).