Paul Christian Scheer was born in Huntington, New York, on January 31, 1976. He attended St. Anthony's High School in Huntington, and then went on to study communication and education at New York University.

After graduating from NYU, Scheer began his comedy career with the Upright Citizens Brigade, a sketch comedy troupe based in New York City. He also began appearing in television and film roles, including a recurring role on the MTV sketch comedy series Human Giant.

In 2009, Scheer co-created and starred in the Adult Swim comedy series NTSF:SD:SUV::. The show ran for three seasons and was a critical and commercial success. Scheer also co-created and starred in the FX/FXX comedy series The League, which ran for seven seasons.

In addition to his television work, Scheer has also had a successful film career. He has appeared in films such as The Hangover, The Disaster Artist, and The Lego Movie 2. He is also a co-host of the popular podcast How Did This Get Made?, which discusses bad movies.

Scheer is married to actress June Diane Raphael, and they have two sons. He is a frequent collaborator with his wife and longtime friend Jason Mantzoukas.

Scheer is 5 feet 10 inches (1.78 meters) tall.