Eric Mayne (April 28, 1865 – February 10, 1947) was an Irish born American actor.

Mayne was born in Dublin and was a star on stage in London in the early 20th century, at the London Lyceum and at Drury Lane. In 1908 and 1910 he played Prince Hildred in The Prince and the Beggar Maid at the Lyceum Theatre in London.

He appeared in the films The New York Peacock, Wife Number Two, Her Hour, Help! Help! Police!, Marooned Hearts, The Conquering Power, Turn to the Right, The Prisoner of Zenda, Pawned, Dr. Jack, My American Wife, The Christian, Suzanna, Prodigal Daughters, Human Wreckage, Her Reputation, Cameo Kirby, The Drums of Jeopardy, Black Oxen, The Yankee Consul, Gerald Cranston's Lady, Her Night of Romance, The Scarlet Honeymoon, Cyclone Cavalier, East Lynne, Hearts and Spangles, Folly of Youth, Money to Burn, Married Alive, The Canyon of Adventure, Rackety Rax, Night of Terror, The Drunkard and Ticket to Paradise, among others.

Mayne died in his sleep in Hollywood, California, on February 10, 1947.