Engy Wegdan graduated from the American University of Cairo in 2004, with a major in Mass Comm. and a double minor in architecture and theater. She began her career teaching English at a language institute, but later quit to work as a film editor for Rotana TV channel in 2004. After 1 year, Engy left to Dubai, were she continued as a film editor for Dubai's Elwaha Channel, until her return to Cairo the following year. Following her return, she edited music video clips such as the song "Try" by Hikmat, as well as advertising work for various ad agencies in Cairo.

Her first appearance as an actress began in 2006, as Dalia, Tamer's sister in the hit TV show "Tamer and Showkeya".

She is most well known for her role as "Arwah", the rambunctious, quick-witted lawyer in the movie "H. Dabbour." She later reprised her role as Arwah in a brief cameo appearance in the movie "Teer Inta".